Dr. Paula Meleady
Dr Paula Meleady is a Principal Investigator at The Life Science Institute and an Associate Professor in the School of Biotechnology, Dublin City University. She is also a Principal Investigator in Rinn Pharma and Biopharma.
Her research focuses on the use of proteomic and mass spectrometry technologies to characterise recombinant mammalian cells, as well as cancer proteomic research.
Research Interests
Dr Meleady's research interests are in the area of Biopharmaceutical Research of CHO cells where she uses proteomic characterisation of recombinant mammalian cells (Chinese hamster ovary (CHO) cells) in order to gain insights to improving productivity of biopharmaceuticals. This involves the analysis of CHO cells under varying bioprocess relevant conditions in order to identify targets that will be used to genetically engineer CHO cells to produce recombinant product (e.g. monoclonal antibodies) more efficiently. She also has particular expertise in the analysis of cellular post-translational modifications (e.g. phosphorylation, ubiquitination, etc.) that play important roles in bioprocess-relevant phenotypes such as growth and productivity Paula also has research interests in Clinical Proteomics including the proteomic analysis of membrane proteins from cancer (pancreatic cancer/uveal melanoma) in order to identify cell surface targets that may be amenable to therapeutic intervention, e.g. with monoclonal antibody and/or antibody drug conjugate (ADC) therapies.